Under the Surface is a podcast hosted by Chemical Computing Group, where we have in-depth discussions on computer-aided techniques in drug discovery.
Chemical ...
9. Rebecca Swett on The Power of Automation in Drug Development
In our final episode of 2024, host Chris Williams and guest co-host, Under the Surface Executive Producer and CCG Vice President, Alain Deschênes have a long overdue chat with computational drug discovery rock star Rebecca Swett. Rebecca shares her journey from her academic beginnings to her current role at X-Chem, via roles at Novartis, Vertex, and Relay. Rebecca’s wide-ranging experience shines through as the conversation wends its way through cutting-edge computational chemistry covering machine learning, molecular dynamics, and DNA-encoded libraries. At the scale Rebecca works at, automation is key, so this topic comes up too. We’re not going to lie; it’s a lot. And, of course, there’s more … Rebecca highlights the significance of allyship and representation for women in science, and the role of community (with a shout-out to the long-running BAGIM modeling forum). Also, in the inaugural asking of the ‘Deschênes Dilemma,’ we find out what Rebecca would be doing if she wasn’t doing all of the above …
--------
46:43
8. The Molecular Assassin
On episode 8 of Under the Surface, we’re joined by The Molecular Assassin, Arijit Basu. Arijit describes his journey from India to the US via a transformative sabbatical in Israel. Landing in the Langer lab at MIT and then finding his industrial legs, Arijit turns to computational toxicology as a way to ensure that drug hunters enable the concept of Safety by Design as a core tenant for how they’re navigating chemical space. He doesn’t discuss how he got his cool nickname though, so if that’s what you’re after, you will be out of luck. This episode was recorded live in Montreal at our 2024 UGM.
--------
42:49
7. On Being The First [Second?]
This next episode of Under the Surface has us speaking to crystallographer Eric Larson. In episode 7, as you’ll hear, Eric’s a little nervous about having his thoughts committed to ‘perpetuity.’ But, as you’ll also hear, he does a great job. As our first second structural biologist on the show, he tells us about how he got into the field, the very real logistical challenges of working in industry, and his evocative description of what it feels like to peek ‘behind the veil’ and be the first on the planet to observe the structure of a previously unknown protein. It’s a magical episode This episode was recorded live in Montreal at our 2024 UGM.
--------
45:24
6. Revolutionizing Nanoscale Visualization
Check out the next episode of our podcast, Under the Surface! In episode 6, Revolutionizing Nanoscale Visualization, we talk to Nanome CEO and co-founder Steve McCloskey. In a virtual rollercoaster of a conversation, he shares Nanome’s scrappy beginnings, the challenge and excitement of bringing new ways of interacting with models to the science community, and paints a vivid picture of an exciting element of the future of molecular modeling. It’s Reality Jim, but not as we know it… Interested in giving this a test drive? Contact [email protected] to set up a demo with Nanome.
--------
1:15:02
5. Farm to Pharma
In episode 5, Farm to Pharma, we talk to Dr. Dan McKay about his career in the pharmaceutical industry (he grew up on a Farm! See what we did there … ?). As a pioneer in the applied use of quantum mechanics, Dan describes his break into the industry from academia, his realization of the critical importance of water in understanding ‘what’s going on’, and offers some pointed observations on the applicability of artificial intelligence and machine learning in drug discovery. Throughout our time with him, Dan’s stories paint a vivid and exciting picture of what it means to support a modern discovery effort. Also, in a first for Under the Surface, we ask something of you, our audience. Can you help us, help Dan?
Under the Surface is a podcast hosted by Chemical Computing Group, where we have in-depth discussions on computer-aided techniques in drug discovery.
Chemical Computing Group (CCG) is a leading supplier of computational chemistry and drug discovery software. CCG's main software platform is the Molecular Operating Environment ("MOE"), which is a single package for visualization, molecular modeling, computer-aided molecular design ("CAMD"), cheminformatics, bioinformatics and methodology development. CCG also produces PSILO, a protein structure repository. For additional information, please visit: www.chemcomp.com.
Sverige