Ep. 81 - Data-Driven Growth: Immunocore CEO Bahija Jallal on Expanding TCR Therapies
On the latest episode of The BioCentury Show, Editor in Chief Simone Fishburn speaks with Bahija Jallal, CEO of Immunocore and the former president of Medimmune. While some biotechs are circumspect about gathering data during clinical trials that might not support the product in question, Jallal sees it as part of the obligation to patients and the field to learn as much as possible, as efficiently as possible. And that strategy has informed how the company will take its TCR technology into earlier lines of treatment and new indications.View full story: https://www.biocentury.com/article/655504#biopharma #pharma #biotech #lifescience #RandD #DrugDevelopment #CEO00:00 - Introduction04:18 - Getting a New Modality to Market17:15 - Infectious Pipeline22:04 - Autoimmune Pipeline27:24 - Leading in Challenging Times
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Ep. 80 - Vertex’s Winning Formula: Altshuler on Choosing the Next Breakthroughs
Vertex’s approach to research, defined over a decade ago to beat the dismal odds of success in biotech, remains core to its strategy, even as the industry evolves and technologies expand. While that strategy, which EVP and CSO David Altshuler calls “serial innovation,” has seen the company launch eight drugs since 2011 and jump market cap tiers on the success of its cystic fibrosis portfolio, it’s now being tested in other areas as Vertex expands to pain, renal disease, Type I diabetes, and more. In conversation with Editor in Chief Simone Fishburn on The BioCentury Show, Altshuler discussed the rising interest in causal biology and the role of AI, noting that the fundamentals of picking targets and programs have not changed.View full story: https://www.biocentury.com/article/655408#biotech #biopharma #pharma #lifescience#RandD #DrugDevelopment #AI00:00 - Introduction02:12 - Causal Biology08:48 - AI in R&D, at Vertex16:35 - Academia-Industry Interface22:00 - Cell Therapy for Diabetes25:35 - Gene Therapy for DMD
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Ep. 79 - BNP Paribas’ Moneer on Biotech’s Bull Case: M&A, PE, and Market Recovery
Since the annual J.P. Morgan Healthcare Conference in San Francisco in early January, biotech has seen a notable surge in enthusiasm, Zahid Moneer, senior managing director of investment banking at BNP Paribas, told The BioCentury Show.Moneer, who is more upbeat than many in today’s biopharma sector, sees capital raises from million-dollar seed rounds to nine-digit series A, B, and C rounds driving significant growth alongside M&A activity. In the interview, he also also highlights the growing role of private equity firms in biopharma and the trend of pharmas engaging earlier with biotechs and investors looking to deploy capital into those companiesView full story: https://www.biocentury.com/article/655216#biotech #biopharma #pharma #lifescience #financing #privateequity #IPO00:00 - Introduction00:37 - Investment Climate05:06 - Pharma M&A Activity15:25 - Private Equity's Role21:44 - Biotech Financing
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Ep. 78 - Biotech’s New Normal: SR One’s Simeon George on Adapting to Market Constraints
Biotechs need to get used to the new normal, says SR One CEO and Managing Partner Simeon George, and that will require significant adjustments to the business model. This new normal comes from an extended tough capital environment against a backdrop of political uncertainty, but while biotechs face a different set of factors than they have in the past, there are still first principles of value creation that should guide them.George, who co-founded SR One management in 2020 following its spinout from GSK, spoke on The BioCentury Show with Editor in Chief Simone Fishburn about the challenges facing biotechs and how VCs are navigating through the complexity of the moment. He also discussed SR One’s strategy and philosophy of investing.View full story: https://www.biocentury.com/article/65514200:00 - Introduction01:31 - Meeting the Moment04:45 - Company Valuations13:54 - China Strategy, NewCos22:08 - Building Successful Biotechs#biotech #biopharma #pharma #lifescience #CEO #financing #newco
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Ep. 77 - AI’s Next Leap: Foresite Labs’ Vik Bajaj on Predictive Biology
Clinical trials will be launched in the next year or two to test predictions about causal biology made by artificial intelligence models, Vik Bajaj, co-founder and CEO of Foresite Labs and managing director of Foresite Capital Management, believes. Foresite teamed up with Arch Venture Partners last year on a $1 billion venture round to fund Xaira Therapeutics, which aims to reinvent the R&D process via AI-driven protein design and biological discovery technologies.Bajaj, who serves as interim president of Xaira, discussed the potential for artificial intelligence to accelerate biomedical progress in an interview with Washington Editor Steve Usdin on The BioCentury Show.View full story: https://www.biocentury.com/article/654977#biotech #biopharma #pharma #lifescience #AI #RandD #drugdiscovery00:00 - Introduction01:18 - AI & Biotech12:19 - Getting the Data Right19:06 - Healthcare Delivery30:47 - Making It Real
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