The Dr. Gabrielle Lyon Show

• GLP-1 & PCOS Breakthroughs: How Ozempic is Changing Women’s Health | Dr. Melanie Cree

  In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex condition—from insulin resistance and mitochondrial dysfunction to skeletal muscle quality and fertility trajectories across a woman’s lifespan.We cover:Why PCOS isn’t a single disease—and what two phenotypes may explain the full pictureHow muscle, liver, and fat interact in PCOSThe misunderstood role of testosterone, insulin, and SHBG in diagnosisWhat muscle biopsies reveal about teenage girls with PCOSIntramuscular fat, mitochondrial impairment, and the true cost of sedentary muscleHow early lifestyle and exercise interventions could change the future of PCOS careWhat GLP-1 agonists and amino acid supplements might offer for treatmentWhether you’re a clinician, patient, or advocate for women’s health, this episode will give you a whole new lens on PCOS—and why skeletal muscle may be the most overlooked (and powerful) organ in the conversation.Who is Dr. Melanie Cree?Dr. Melanie Cree is a board-certified pediatric endocrinologist and Associate Professor at the University of Colorado and Children’s Hospital Colorado, where she directs a leading multidisciplinary PCOS clinic. Her research bridges metabolic medicine and muscle physiology, with clinical trials exploring semaglutide, amino acid therapy, liver metabolism, and insulin resistance in adolescents.Forever Strong Summit 2025: The Forever Strong Summit is a live event on April 27, 2025 in Houston, TX, designed to help you build strength, resilience, and longevity from the inside out. Featuring top minds in medicine, military, and mindset, you’ll walk away with practical tools to upgrade your health, sharpen your focus, and take ownership of your life. Whether you're a clinician, athlete, or simply ready to step into your next level—this is where science meets action. Get your ticket now! https://drgabriellelyon.com/forever-strong-summit-2025/ This episode is brought to you by:LMNT – Get your free LMNT Sample Pack with any purchase → DrinkLMNT.com/DRLYONCozy Earth – Get up to 40% off with code DRLYON → cozyearth.com/DRLYONOneSkin – Get 15% off with the code DRLYON at → OneSkin.coTimeline Nutrition – Get 10% off → timeline.com/LYONFind Dr. Melanie Cree at: University of Colorado - https://som.cuanschutz.edu/Profiles/Faculty/Profile/22449Find me at:Instagram: @drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube:

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• The Science of Joint Health: How to Keep Your Bones Strong for Life | Dr. Jocelyn Wittstein

  In this episode, I’m joined by Dr. Jocelyn Wittstein—orthopedic surgeon, sports medicine expert, and Associate Professor at Duke University—for a powerful and practical conversation about bone and joint health across the lifespan. From the challenges of frozen shoulder and arthritis to the truth about running and menopause hormone therapy, this episode is your definitive guide to staying strong, mobile, and pain-free well into your 40s, 50s, and beyond.We cover:Why your joints and bones start changing after 30—and what to do about itThe difference between male and female aging (and why 50 hits women harder)The role of estrogen in health, inflammation, muscle mass, and osteoporosisThe truth about running and arthritis: myth vs. realityHow to actually build stronger bones: plyometrics, impact, and intensityWhy frozen shoulder happens and how to treat it earlyThe supplements Dr. Wittstein actually recommends (and which ones she used to dismiss)What we’re learning about GLP-1 medications and their surprising effect on bone and joint healthWhether you’re an athlete, a parent, or entering perimenopause, this conversation is a masterclass in movement longevity and joint and bone preservation.Who is Dr. Jocelyn Wittstein?Dr. Jocelyn Wittstein is an Associate Professor of Orthopedic Surgery at Duke University specializing in sports medicine and women's joint health. As a leading researcher and clinician, she’s pioneered work on arthritis, adhesive capsulitis, and the role of hormones in bone and joint aging. She is also co-author of the upcoming book The Complete Bone and Joint Health Plan (May 2025), a practical guide for women who want to move well and stay strong at every stage of life.This episode is brought to you by:Puori – Code DRLYON for 20% off sitewide! → puori.com/DRLYONNeeded – Code DRLYON for 20% off your first order → thisisneeded.comBON CHARGE – Code DRLYON for 15% off! → boncharge.com/DRLYONDivi – Get 20% off your first order → diviofficial.com/DRLYONFind Dr. Jocelyn Wittstein at: Duke Health: https://www.dukehealth.org/find-doctors-physicians/jocelyn-ross-wittstein-md Instagram: @jocelyn_wittstein_mdThe Complete Bone and Joint Health Plan: Amazon and Barnes & Noble Find me at:Instagram: @drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube:youtube.com/@DrGabrielleLyonX (Twitter):

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• Resilient by Design: A Navy SEAL-Turned-Doctor’s Roadmap to Success | Shane Kronstedt MD

  In this episode, I’m joined by Dr. Shane Kronstedt—former Navy SEAL, physician, surgical resident, and most importantly, my husband—for a powerful conversation about discipline, resilience, and the real-life moments that define us. From his early years of martial arts and mixed martial arts to surviving Hell Week and life-or-death missions in Afghanistan and Uganda, Shane shares how pressure creates clarity, why mindset matters most, and what it truly means to lead by example. This deeply personal episode gives you a rare glimpse into the man behind the mission.We cover:Why Shane chose the most dangerous path on purpose—and what it taught himWhat Hell Week is really like (and why most fail)His perspective on “one moment of weakness for a lifetime of regret”Lessons learned from combat trauma and performing surgery in war zonesThe truth about motivation, mental toughness, and doing things that suckWhy preparation beats panic and mindset > emotionThe relationship between high performers, adversity, and identityWhat it’s like building a family, business, and legacy Whether you’re a parent, athlete, medical professional, or someone who wants to be better under pressure, this episode will challenge you to redefine your limits and commit to something greater than yourself.Please be advised: This episode contains some strong language and may not be suitable for all audiences. Who is Shane Kronstedt?Dr. Shane Kronstedt Shane was a Navy SEAL and combat medic with ten years of active duty service. His time overseas treating patients inspired him to become a surgeon. He deployed to Afghanistan, Europe, the Horn of Africa, and South America. Some of his awards include the Navy Commendation Medal, the Army Commendation Medal, The Joint Services Achievement Medal, and Navy Achievement Medal x2. He graduated from Rutgers Robert Wood Johnson Medical School with AOA Honors in 2023 and is currently a resident in urologic surgery at Baylor College of Medicine. This episode is brought to you by:LMNT – Get your free LMNT Sample Pack with any purchase – DrinkLMNT.com/DRLYONAG1 – FREE bottle of D3K2 and 5 free travel packs at DrinkAG1.com/LYONOneSkin – Get 15% off with the code DRLYON at https://www.oneskin.co/ Timeline Nutrition – Get 10% off at https://Timeline.com/LYONFind me at: Instagram: @drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube:youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.pageGet my book –

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  1:40:08
• Comfort is Destroying Your Health: Why Stress is Not the Enemy | Jeff Krasno

  Jeff Krasno’s personal health transformation—reversing diabetes, shedding 60 pounds, and reclaiming his health at age 50—is a masterclass in what he calls “good stress.” In this episode, we dive into the simple but powerful idea that discomfort might just be the medicine we all need. Jeff, the founder of Commune and host of the Commune podcast, shares how fasting, cold exposure, resistance training, and attention to modern habits helped him regain his energy, build muscle, and thrive.Together, we discuss how metabolic dysfunction has become the norm, how adaptive stress responses can be harnessed to reverse chronic illness, and why building muscle is not only the antidote to obesity but also a critical factor in longevity. If you’re interested in reclaiming your vitality and learning how to work with—not against—your biology, this episode will speak to you.We cover:Jeff’s story of personal health transformation at midlifeWhat “good stress” is and how to harness it to improve healthWhy chronic ease leads to chronic diseaseCold therapy, fasting, and training as adaptive stressorsThe importance of resistance training for blood sugar controlHow metabolic dysfunction hides in plain sightPractical tips to increase non-exercise activity thermogenesis (NEAT)Building muscle as the path to longevity and disease preventionWho is Jeff Krasno?Jeff Krasno is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being. He hosts the Commune podcast, where he’s interviewed luminaries like Deepak Chopra, Gabor Maté, and Matthew McConaughey. Jeff also writes a weekly personal essay called “Commusings,” delivered to over a million subscribers every Sunday. His new project, Good Stress, is an online course, upcoming book, and developing TV series, built on the wellness strategies that helped him reclaim his health after a diabetes diagnosis. He is also the co-creator of the global wellness event series Wanderlust and was selected for Oprah’s SuperSoul100 in 2016.This episode is brought to you by:Puori – Code DRLYON for 20% off sitewide! – https://Puori.com/DRLYONARMRA – Code DRLYON for 15% off! – https://armra.com/DRLYONBON CHARGE – Code DRLYON for 15% off! – https://boncharge.com/DRLYONMUD\WTR – Code DRLYON for up to 43% off – http://mudwtr.com/DRLYONFind Jeff Krasno at:Website – https://www.jeffkrasno.comInstagram – https://www.instagram.com/jeffkrasnoLinkedIn – https://www.linkedin.com/in/jeffkrasnoYouTube – https://www.youtube.com/@CommuneGood Stress (Course & Book) – https://www.goodstress.comFind me at:Instagram: @drgabriellelyonTikTok: @drgabriellelyonFacebook:

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  1:46:37
• Steroids & Testosterone: The Science Behind Anabolic Therapies | Nelson Vergel

  Nelson Vergel’s story is one of resilience, perseverance, and an unrelenting drive to defy the odds. In the mid-1980s, he was handed what many would have considered a death sentence—an HIV diagnosis at a time when there were no effective treatments, no clear answers, and little hope. Today, he is a beacon of knowledge and empowerment for those seeking to take control of their health, whether they are dealing with wasting conditions, hormone deficiencies, or simply aiming for peak performance. Nelson has spent decades researching and advocating for hormone health, muscle preservation, and medical autonomy, particularly for those facing wasting conditions like HIV and cancer. His work has helped shape the conversation around androgen therapies, the role of anabolic agents in aging, and the intersection of GLP-1 medications with muscle loss.We cover:Nelson's personal journey from an HIV diagnosis to hormone optimizationThe history, misconceptions and stigma surrounding anabolic agentsThe differences between various anabolic agents and how they work The impact of GLP-1 medications on lean mass and how to mitigate muscle lossBest practices for hormone monitoring and optimizationIf you want to hear an inspiring story of overcoming the odds to take control of your own health or you’re curious about anabolic therapies and longevity, you can’t miss this one. Who is Nelson Vergel?Nelson Vergel is a chemical engineer, author, and health advocate who has made significant contributions to men's health and hormone optimization. His most recent book, Beyond Testosterone, provides a detailed color guide to educate clinicians and patients about the latest advances in the use of testosterone, anabolics, and other therapies to maximize health and productivity.This episode is brought to you by:LMNT - Code DRLYON for a free LMNT Sample Pack! – http://drinklmnt.com/drlyoOur Place - Code DRLYON for 10% off – https://fromourplace.comTimeline - Code DRLYON for 10% OFF – https://timelinenutrition.com/DRLYONOneSkin - Code DRLYON for 15% off! – https://www.oneskin.co/Find Nelson Vergel at:DiscountedLabs.com – Offers affordable blood tests for monitoring hormones and overall health. ExcelMale.com – A leading 14-year forum with over 42,000 members discussing TRT, hormone health, supplements, and fitness. TRT Facebook Group - https://www.facebook.com/groups/testosteronereplacementWomen’s Healthand HRT Group - https://www.facebook.com/groups/womenHRT LinkedIn - https://www.linkedin.com/in/nvergel/Amazon –

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